Ikeda K, Ikeda T, Isshiki A, Miyake T, Herregods L, Rolly G
Department of Anesthesiology, Hachiouji Medical Center.
Masui. 1990 Sep;39(9):1133-7.
We investigated hemodynamic changes in patients undergoing coronary artery bypass grafting (CABG) and valve replacement. The former had been medicated with beta-blocking agent until the morning of operative day. On the other hand, the latter received no medication. We measured systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), heart rate, and rate pressure product (RPP) at the following five points; before induction of anesthesia, immediately before intubation, immediately after intubation, one minute after skin incision and one minute after sternotomy. In both groups, SAP and DAP decreased significantly after induction; heart rate did not change during our study; and RPP decreased significantly after skin incision. There were no significant differences between the group with beta-blocking agent and the group without it. These results suggest that beta-blocking agents exert no influence in our study, and sufentanil-oxygen anesthesia produce hemodynamic stability for open heart surgery.
我们研究了接受冠状动脉旁路移植术（CABG）和瓣膜置换术患者的血流动力学变化。前者在手术当天早晨之前一直服用β受体阻滞剂。另一方面，后者未接受任何药物治疗。我们在以下五个时间点测量收缩压（SAP）、舒张压（DAP）、平均动脉压（MAP）、心率和率压积（RPP）：麻醉诱导前、插管前即刻、插管后即刻、皮肤切开后1分钟和胸骨切开后1分钟。在两组中，诱导后SAP和DAP均显著下降；在我们的研究过程中心率未发生变化；皮肤切开后RPP显著下降。服用β受体阻滞剂组和未服用β受体阻滞剂组之间无显著差异。这些结果表明，在我们的研究中β受体阻滞剂未发挥作用，舒芬太尼 - 氧气麻醉可为心脏直视手术产生血流动力学稳定性。
