以神经保护为靶点，作为预防和治疗神经病理性疼痛的一种替代方法。
Targeting neuroprotection as an alternative approach to preventing and treating neuropathic pain.
机构信息
Trophos, Parc Scientifique de Luminy, Luminy Biotech Entreprises, 13288 Marseille, France.
出版信息
Neurotherapeutics. 2009 Oct;6(4):648-62. doi: 10.1016/j.nurt.2009.07.001.
Abstract
Neuropathic pain syndromes arise from dysfunction of the nerve itself, through traumatic or nontraumatic injury. Unlike acute pain syndromes, the pain is long-lasting and does not respond to common analgesic therapies. Drugs that disrupt nerve conduction and transmission or central sensitization, currently the only effective treatments, are only modestly effective for a portion of the patients suffering from neuropathic pain and come with the cost of serious adverse effects. Neurodegeneration, as a reaction to nerve trauma or chronic metabolic or chemical intoxication, appears to be an underlying cause of neuropathic pain. Identifying mechanisms of neurodegeneration and designing neuroprotective therapies is an ambitious goal toward treating or even preventing the development of these disabling disorders.
摘要
神经病理性疼痛综合征源于神经本身的功能障碍，可由创伤或非创伤性损伤引起。与急性疼痛综合征不同，其疼痛持续时间长，且对常用的镇痛疗法没有反应。目前唯一有效的治疗方法是破坏神经传导和传递或中枢敏化的药物，但对部分患有神经病理性疼痛的患者仅有一定的疗效，且存在严重不良反应的风险。神经退行性变是神经损伤或慢性代谢或化学中毒的反应，似乎是神经病理性疼痛的潜在原因。确定神经退行性变的机制并设计神经保护疗法是治疗甚至预防这些致残性疾病发展的一个宏伟目标。
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