卡培他滨引起的酷似心肌梗死的心脏毒性。
Capecitabine-induced cardiotoxicity mimicking myocardial infarction.
机构信息
Department of Cardiology, Uludag University School of Medicine, Görükle, Bursa, Turkey.
出版信息
Neth Heart J. 2009 Aug;17(7-8):277-80. doi: 10.1007/BF03086265.
Abstract
Capecitabine, a fluoropyrimidine derivative, is an orally administered drug that delivers 5-fluorouracil (5-FU) selectively to the tumour. The drug has demonstrated activity in metastatic colorectal cancer. We describe a male patient receiving capecitabine therapy with typical chest pain and electrocardiographic changes consistent with STsegment elevation myocardial infarction. Capecitabine-induced cardiotoxicity may develop in patients who have had a previous episode of 5-FU-induced cardiotoxicity. Capecitabine-induced cardiotoxicity is a rare condition that may lead to diagnostic and therapeutic dilemmas. (Neth Heart J 2009;17:277-80.).
摘要
卡培他滨是一种氟嘧啶衍生物，是一种口服药物，可将 5-氟尿嘧啶（5-FU）选择性地递送到肿瘤部位。该药物在转移性结直肠癌中具有活性。我们描述了一名接受卡培他滨治疗的男性患者，他出现典型胸痛和心电图变化，符合 ST 段抬高型心肌梗死。曾有 5-FU 诱导性心脏毒性发作的患者可能会发生卡培他滨诱导性心脏毒性。卡培他滨诱导性心脏毒性是一种罕见的病症，可能导致诊断和治疗上的困境。（荷兰心脏杂志 2009；17:277-80.）。
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