Department of Neurology, Higashi-Saitama National Hospital, Hasuda, Saitama, Japan.
J Neurol. 2010 Mar;257(3):419-25. doi: 10.1007/s00415-009-5338-5. Epub 2009 Sep 30.
We investigated a progression of brain atrophy and somatosensory system dysfunction in multiple system atrophy (MSA). Subjects were 21 MSA patients [12 MSA-C (cerebellar type) and 9 MSA-P (parkinsonism type)]. The relative volumes of cerebrum, brainstem and cerebellum to the intracranial volume were obtained from three-dimensional computed tomography (3D-CT) of the brain. The median nerve somatosensory evoked potentials (SEPs) were recorded, and the latencies and amplitudes of N9, N11, P13/14, N20 and P25 components were measured. We studied correlations between brain volumes, SEP and clinical features. The brainstem and cerebellar atrophies were aggravated with progression of the disease. The central sensory conduction time (CSCT) was progressively prolonged in parallel with the disease duration irrespective of the actual age of the patients. In MSA patients, the volume reductions of cerebellum and brainstem could be one of structural markers of disease progression, and the sensory pathway is progressively involved with the progression of disease processes.
我们研究了多系统萎缩（MSA）中脑萎缩和躯体感觉系统功能障碍的进展。研究对象为 21 例 MSA 患者[12 例 MSA-C（小脑型）和 9 例 MSA-P（帕金森型）]。通过脑部三维 CT（3D-CT）获得大脑的脑实质、脑干和小脑相对于颅内容积的相对容积。记录正中神经躯体感觉诱发电位（SEP），并测量 N9、N11、P13/14、N20 和 P25 成分的潜伏期和振幅。我们研究了脑体积、SEP 和临床特征之间的相关性。随着疾病的进展，脑干和小脑萎缩加重。无论患者的实际年龄如何，中枢感觉传导时间（CSCT）都随着疾病持续时间的延长而逐渐延长。在 MSA 患者中，小脑和脑干的体积减少可能是疾病进展的结构标志物之一，并且感觉通路随着疾病进程的进展而逐渐受到影响。
