Fachgruppe Chemie, Bergische Universität Wuppertal, Gaussstrasse 20, 42119 Wuppertal, Germany.
Chembiochem. 2009 Nov 2;10(16):2644-53. doi: 10.1002/cbic.200900450.
Neuropeptides control essential physiological processes in insects such as water balance and muscle activity. Due to their metabolic instability and adverse physiochemical properties, insect neuropeptides are unsuited for a direct application in plant protection. As a first approximation towards the biologically active conformation, the structures of selected neuropeptides from economically important pest insects were determined by NMR spectroscopy and fluorescence measurements in a membrane-mimicking environment. A receptor binding model is suggested for the helicokinins and discussed in connection with biological activities and membrane-bound conformations of linear and cyclic analogues.
神经肽控制着昆虫的基本生理过程，如水平衡和肌肉活动。由于其代谢不稳定性和不良的物理化学性质，昆虫神经肽不适合直接应用于植物保护。作为对生物活性构象的初步近似，通过 NMR 光谱和在模拟膜环境中的荧光测量，确定了来自经济重要害虫的选定神经肽的结构。提出了一种螺旋肽的受体结合模型，并结合线性和环状类似物的生物活性和膜结合构象进行了讨论。
