Speciali G G, Lison M P
Arq Neuropsiquiatr. 1977 Sep;35(3):218-27. doi: 10.1590/s0004-282x1977000300005.
The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed. The effect of each drug on seizures (tonic, tonic-clonic, clonic, myoclonic or myoclonic-atonic, atonic and atypical absences) during the first month of each treatment is discussed. The "specific" use of each drug on the various forms of epileptic seizures is determined and the possibility of crisis control with reduction of the drugs dosage is verified.
对29例Lennox-Gastaut综合征患者使用不同药物(地西泮、硝西泮、氯硝西泮、苯妥英钠、巴比妥类药物——苯巴比妥和扑米酮——、丙戊酸钠和促肾上腺皮质激素)的治疗结果进行了仔细分析。讨论了每种药物在每次治疗的第一个月对癫痫发作(强直、强直阵挛、阵挛、肌阵挛或肌阵挛失张力、失张力和非典型失神)的影响。确定了每种药物对各种癫痫发作形式的“特异性”用途,并验证了通过减少药物剂量控制发作的可能性。