Willoughby J O, Kapoor R
Centre for Neuroscience, Flinders Medical Centre, Bedford Park, South Australia.
Neuropeptides. 1990 Mar;15(3):153-6. doi: 10.1016/0143-4179(90)90147-q.
The distribution of somatostatin and growth hormone releasing factor (GRF) fibres in the hypothalamus suggests that they may be involved in physiological functions in addition to growth hormone control. GRF or somatostatin were stereotaxically injected into anterior or basal hypothalamic regions of unanesthetized male rats and effects on plasma prolactin measured. Somatostatin caused a small, significant, dose-responsive stimulation of prolactin secretion when injected in both hypothalamic regions, while GRF was without effect. Somatostatin may therefore have a minor intrahypothalamic role in regulating prolactin.
生长抑素和生长激素释放因子（GRF）在下丘脑中的纤维分布表明，它们可能除了控制生长激素外，还参与生理功能。将GRF或生长抑素立体定位注射到未麻醉雄性大鼠的下丘脑前部或基底区域，并测量对血浆催乳素的影响。当在下丘脑两个区域注射时，生长抑素对催乳素分泌产生小的、显著的、剂量依赖性刺激，而GRF则无作用。因此，生长抑素可能在下丘脑内对催乳素调节起次要作用。
