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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bjerregaard H F, Nielsen R

Institute of Life Sciences and Chemistry, University of Roskilde, Denmark.

Comp Biochem Physiol A Comp Physiol. 1990;97(1):75-80. doi: 10.1016/0300-9629(90)90724-7.

The role of prostaglandins and intracellular Ca2+ in regulation of active transepithelial sodium transport in frog skin were studied by examinations of effects of the calcium ionophore A23187 on short-circuit current (SCC) and intracellular voltage. 2. A23187 and arachidonic acid induced a marked increase in both SCC and prostaglandin E2 synthesis. 3. In indomethacin treated skins A23187 did not stimulate but on the contrary inhibited the basal SCC. 4. The A23187-induced increase in SCC was associated with a decrease in the fractional resistance of the apical membrane and a depolarization of the cells. 5. In skins pretreated with indomethacin, the A23187 induced inhibition of SCC coincided with a slight hyperpolarization of the cellular potential and an increase in fractional resistance of the apical membrane.

通过检测钙离子载体A23187对短路电流（SCC）和细胞内电压的影响，研究了前列腺素和细胞内Ca2+在蛙皮主动跨上皮钠转运调节中的作用。2. A23187和花生四烯酸均引起SCC和前列腺素E2合成显著增加。3. 在吲哚美辛处理的皮肤中，A23187并未刺激基础SCC，反而抑制了它。4. A23187引起的SCC增加与顶端膜的分数电阻降低及细胞去极化有关。5. 在吲哚美辛预处理的皮肤中，A23187引起的SCC抑制与细胞电位轻微超极化及顶端膜分数电阻增加同时出现。

Bjerregaard H F, Nielsen R

Institute of Life Sciences and Chemistry, University of Roskilde, Denmark.

Comp Biochem Physiol A Comp Physiol. 1990;97(1):75-80. doi: 10.1016/0300-9629(90)90724-7.

The role of prostaglandins and intracellular Ca2+ in regulation of active transepithelial sodium transport in frog skin were studied by examinations of effects of the calcium ionophore A23187 on short-circuit current (SCC) and intracellular voltage. 2. A23187 and arachidonic acid induced a marked increase in both SCC and prostaglandin E2 synthesis. 3. In indomethacin treated skins A23187 did not stimulate but on the contrary inhibited the basal SCC. 4. The A23187-induced increase in SCC was associated with a decrease in the fractional resistance of the apical membrane and a depolarization of the cells. 5. In skins pretreated with indomethacin, the A23187 induced inhibition of SCC coincided with a slight hyperpolarization of the cellular potential and an increase in fractional resistance of the apical membrane.

通过检测钙离子载体A23187对短路电流（SCC）和细胞内电压的影响，研究了前列腺素和细胞内Ca2+在蛙皮主动跨上皮钠转运调节中的作用。2. A23187和花生四烯酸均引起SCC和前列腺素E2合成显著增加。3. 在吲哚美辛处理的皮肤中，A23187并未刺激基础SCC，反而抑制了它。4. A23187引起的SCC增加与顶端膜的分数电阻降低及细胞去极化有关。5. 在吲哚美辛预处理的皮肤中，A23187引起的SCC抑制与细胞电位轻微超极化及顶端膜分数电阻增加同时出现。