[非苯二氮䓬类物质的5-羟色胺阳性与抗焦虑活性的相关性]
[The correlation of the serotonin-positive and anxiolytic activities of nonbenzodiazepine substances].
作者信息
Abramets I I, Dolzhenko A T, Komissarov I V, Samoĭlovich I M, Talalaenko A N, Kharin N A
出版信息
Farmakol Toksikol. 1990 Sep-Oct;53(5):13-6.
The anxiolytic activity of serotonin agonists (buspirone, ipsapirone, campirone, caplapirone, 1-pyrimidinyl-piperazine) determined in rats on 3 experimental models of anxiety closely correlates with the degree of inhibition of impulse release of 3H-serotonin by electrically stimulated slices of the midbrain raphe dorsal nucleus (r = +0.85) but not the slices of the cerebral hemispheric cortex (r = +0.60) of the rats. The anxiolytic activity of neuroleptics (chlorpromazine, trifluorperazine), antidepressant (amitriptyline, imipramine) and beta-carbolines (harmane, 3.4-tetramethyleneharmane) corresponds well (r = +0.94) to the ability of the drugs to potentiate the hyperpolarizing effects of serotonin in the rat sensory ganglion.
在大鼠身上的3种焦虑实验模型中测定的血清素激动剂（丁螺环酮、伊沙匹隆、坎匹隆、卡普拉匹隆、1-嘧啶基-哌嗪）的抗焦虑活性，与大鼠中脑缝际背核电刺激切片对3H-血清素冲动释放的抑制程度密切相关（r = +0.85），但与大鼠大脑半球皮质切片（r = +0.60）的抑制程度无关。抗精神病药物（氯丙嗪、三氟拉嗪）、抗抑郁药（阿米替林、丙咪嗪）和β-咔啉（哈尔满、3,4-四亚甲基哈尔满）的抗焦虑活性与这些药物增强大鼠感觉神经节中血清素超极化作用的能力高度相符（r = +0.94）。
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