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An HhaI polymorphism is present in factor IX genes of Asian subjects.

作者信息

Reiner A P, Thompson A R

机构信息

Puget Sound Blood Center, Seattle, WA 98104.

出版信息

Hum Genet. 1990 Nov;86(1):87-8. doi: 10.1007/BF00205181.

DOI:10.1007/BF00205181
PMID:1979312
Abstract

Hemophilia B is caused by decreased factor IX procoagulant activity. An HhaI restriction site polymorphism near the factor IX gene has been detected by the polymerase chain reaction. Frequency and linkage data already observed in Caucasians are confirmed and the polymorphism is also prevalent in the factor IX genes of Black and Asian populations.

摘要

相似文献

1
An HhaI polymorphism is present in factor IX genes of Asian subjects.
Hum Genet. 1990 Nov;86(1):87-8. doi: 10.1007/BF00205181.
2
A second BamHI DNA polymorphism and haplotype association in the factor IX gene.凝血因子IX基因中的第二种BamHI DNA多态性及单倍型关联
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3
DGGE detection of HhaI polymorphism in the F9 gene.F9基因中HhaI多态性的变性梯度凝胶电泳（DGGE）检测
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Factor IX gene haplotypes in Brazilian blacks and characterization of unusual DdeI alleles.巴西黑人中的凝血因子IX基因单倍型及异常DdeI等位基因的特征分析
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The varying frequencies of five DNA polymorphisms of X-linked coagulant factor IX in eight ethnic groups.八个种族群体中X连锁凝血因子IX的五种DNA多态性的不同频率。
Am J Hum Genet. 1991 Sep;49(3):537-44.
6
An MseI RFLP in the 5' flanking region of the factor IX gene: its use for haemophilia B carrier detection in Caucasian and Thai populations.
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7
The factor IX BamHI polymorphism: T-to-G transversion at the nucleotide sequence -561. The BamHI/MSPI haplotypes in blacks and Caucasians.
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Detection of the Taq 1 polymorphism of the factor IX gene by P.C.R.通过聚合酶链反应检测凝血因子IX基因的Taq 1多态性
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9
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Diagnostic role of an immunoassay-detected polymorphism of factor IX for potential carriers of hemophilia B.
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引用本文的文献

1
CG dinucleotide transitions in the factor IX gene account for about half of the point mutations in hemophilia B patients: a Seattle series.凝血因子IX基因中的CG二核苷酸转换约占B型血友病患者点突变的一半：西雅图系列研究。
Hum Genet. 1991 Jun;87(2):177-82. doi: 10.1007/BF00204177.

本文引用的文献

1
Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).凝血因子IX基因（B型血友病位点）在人类X染色体上的区域定位及多态性
Proc Natl Acad Sci U S A. 1984 Jan;81(2):498-502. doi: 10.1073/pnas.81.2.498.
2
Carrier detection in haemophilia B using two further intragenic restriction fragment length polymorphisms.利用另外两种基因内限制性片段长度多态性进行乙型血友病的携带者检测。
Nucleic Acids Res. 1984 Dec 11;12(23):8861-72. doi: 10.1093/nar/12.23.8861.
3
Diagnostic role of an immunoassay-detected polymorphism of factor IX for potential carriers of hemophilia B.
Blood. 1988 Nov;72(5):1633-8.
4
The factor IX BamHI polymorphism: T-to-G transversion at the nucleotide sequence -561. The BamHI/MSPI haplotypes in blacks and Caucasians.
Hum Genet. 1989 Jun;82(3):283-4. doi: 10.1007/BF00291171.
5
Detection of polymorphisms at cytosine phosphoguanadine dinucleotides and diagnosis of haemophilia B carriers.
Lancet. 1989 Mar 25;1(8639):631-4. doi: 10.1016/s0140-6736(89)92141-7.
6
A new MspI restriction fragment length polymorphism in the hemophilia B locus.乙型血友病基因座中一种新的MspI限制性片段长度多态性
Hum Genet. 1985;71(1):79-81. doi: 10.1007/BF00295673.
7
A 50 bp polymorphic insertion in the factor IX gene is readily detected by amplification and is in equilibrium with other polymorphic sites.凝血因子IX基因中一个50碱基对的多态性插入可通过扩增轻易检测到，并且与其他多态性位点处于平衡状态。
Nucleic Acids Res. 1990 Sep 11;18(17):5325. doi: 10.1093/nar/18.17.5325.
8
Molecular biology of the hemophilias.血友病的分子生物学
Prog Hemost Thromb. 1991;10:175-214.