2 型糖尿病合并与不合并缺血性心脏病患者的超声心动图表现和 NT-proBNP 水平。

Echocardiographic findings and NT-proBNP level in type-2 diabetic patients with and without ischemic heart disease.

机构信息

Departamento de Cardiología, Clínica Universidad de Navarra, Pamplona, Navarra, España.

出版信息

Rev Esp Cardiol. 2009 Oct;62(10):1184-8. doi: 10.1016/s1885-5857(09)73334-1.

PMID:19793525

Abstract

The aim of this study was to determine whether there are differences in echocardiographic findings or in the level of a biochemical marker (i.e. N-terminal probrain natriuretic peptide [NT-proBNP]) between controls and type-2 diabetic patients with or without ischemic heart disease. Echocardiography was used to assess left ventricular function and morphology. In addition, the plasma NT-proBNP concentration was measured. The prevalence of diastolic dysfunction was greater in diabetics without ischemic heart disease than in controls (88% vs. 74%, respectively; P< .001) and the NT-proBNP concentration was higher (350.6+/-197.8 vs. 281.7+/-190.4 fmol/mL; P< .001). Diabetics with ischemic heart disease had a higher NT-proBNP concentration than those without (720.4+/-278.1 vs. 350.6+/-197.8 fmol/mL, respectively; P< .001). An NT-proBNP concentration >490 fmol/mL had a sensitivity of 84% and a specificity of 75% for detecting ischemic heart disease in diabetics.

摘要

本研究旨在确定 2 型糖尿病患者是否存在与对照组之间存在超声心动图结果或生化标志物（即 N 末端脑利钠肽前体 [NT-proBNP]）水平的差异，这些患者有无缺血性心脏病。采用超声心动图评估左心室功能和形态。此外，还测量了血浆 NT-proBNP 浓度。与对照组相比，无缺血性心脏病的糖尿病患者舒张功能障碍的患病率更高（分别为 88%和 74%；P<.001），且 NT-proBNP 浓度更高（350.6+/-197.8 比 281.7+/-190.4 fmol/mL；P<.001）。有缺血性心脏病的糖尿病患者的 NT-proBNP 浓度高于无缺血性心脏病的患者（分别为 720.4+/-278.1 和 350.6+/-197.8 fmol/mL；P<.001）。在糖尿病患者中，NT-proBNP 浓度>490 fmol/mL 对缺血性心脏病的检测具有 84%的敏感性和 75%的特异性。