结直肠癌遗传学概述。

Overview of colorectal cancer genetics.

作者信息

Gryfe Robert

机构信息

Department of Surgery, Mount Sinai Hospital and The Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1X5.

出版信息

Surg Oncol Clin N Am. 2009 Oct;18(4):573-83. doi: 10.1016/j.soc.2009.08.004.

DOI:10.1016/j.soc.2009.08.004

PMID:19793566

Abstract

Cancer is a genetic disease in which the clonal accumulation of genetic alterations confers a cell with the malignant characteristics of uncontrolled growth, local invasiveness, and metastastic potential. Studies of colorectal cancer and its precursor lesion, the adenomatous polyp, have served as the cornerstone in advancing knowledge of cancer molecular genetics. The past 30 years have ushered in an era of revolutionary increases in understanding colorectal cancer genetics. In the future, it is hoped that the tremendous recent gains made in understanding colorectal cancer genetics will allow for significant, tailored chemoprevention and treatment of this common malignancy.

摘要

癌症是一种遗传性疾病，其中基因改变的克隆性积累赋予细胞不受控制生长、局部侵袭和转移潜能的恶性特征。对结直肠癌及其前体病变腺瘤性息肉的研究，一直是推动癌症分子遗传学知识进步的基石。过去30年开启了一个在理解结直肠癌遗传学方面取得革命性进展的时代。未来，人们希望最近在理解结直肠癌遗传学方面取得的巨大进展，将能够对这种常见恶性肿瘤进行重大的、量身定制的化学预防和治疗。