Bunker C B, Terenghi G, Springall D R, Polak J M, Dowd P M
Department of Dermatology, University College and Middlesex School of Medicine, London, UK.
Lancet. 1990;336(8730):1530-3. doi: 10.1016/0140-6736(90)93307-b.
Skin biopsy samples from the fingers of nine patients with primary Raynaud's phenomenon, nine with the disorder associated with systemic sclerosis, and eleven healthy controls were examined by immunocytochemistry. There were no differences between the groups in the distribution of PGP 9.5 (a pan-neuronal marker) immunoreactivity, but there was a significant reduction in the number of calcitonin gene-related peptide (CGRP) immunoreactive neurons in the skin of patients with primary Raynaud's phenomenon and those with systemic sclerosis. These findings implicate dysfunction of the CGRP neurovascular axis in the pathophysiology of Raynaud's phenomenon.
通过免疫细胞化学方法检查了9例原发性雷诺现象患者、9例与系统性硬化症相关疾病患者手指的皮肤活检样本以及11名健康对照者的样本。各组间PGP 9.5（一种泛神经元标志物）免疫反应性的分布无差异，但原发性雷诺现象患者和系统性硬化症患者皮肤中降钙素基因相关肽（CGRP）免疫反应性神经元的数量显著减少。这些发现提示CGRP神经血管轴功能障碍在雷诺现象的病理生理学中起作用。
