Simard-Tremblay Elisabeth, Shevell Michael, Dagenais Lynn
Department of Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada.
J Child Neurol. 2010 Jun;25(6):669-73. doi: 10.1177/0883073809342590. Epub 2009 Sep 30.
The objective of this study was to identify factors that predict ambulation in spastic quadriplegic cerebral palsy. A 4-year registry-based birth cohort was searched for patients with a diagnosis of spastic quadriplegic cerebral palsy. All patients were then divided in 2 groups: (a) Gross Motor Function Classification System level < or = III (ambulant group) and (b) Gross Motor Function Classification System level > or = IV (nonambulant group). Clinical features were then compared between the 2 groups. A total of 85 children with a diagnosis of spastic quadriplegic cerebral palsy were identified. Of these, 65 and 20 were classified in the ''nonambulant'' and ''ambulant'' groups, respectively. The presence of seizures in the first 24 or 72 hours of life and the administration of antibiotics during pregnancy/delivery were all associated with an eventual inability to achieve ambulation. A gestational age < or = 27 weeks, birth weight <1000 g, Caucasian mother, and the presence of hyperbilirubinemia were significantly linked with independent ambulation.
本研究的目的是确定预测痉挛性四肢瘫脑瘫患者行走能力的因素。对一个基于登记的4年出生队列进行搜索，以查找诊断为痉挛性四肢瘫脑瘫的患者。然后将所有患者分为两组：(a) 粗大运动功能分类系统水平≤III级（能行走组）和(b) 粗大运动功能分类系统水平≥IV级（不能行走组）。然后比较两组之间的临床特征。共确定了85例诊断为痉挛性四肢瘫脑瘫的儿童。其中，65例和20例分别被归类为“不能行走”组和“能行走”组。出生后最初24小时或72小时内出现癫痫发作以及孕期/分娩期间使用抗生素均与最终无法实现行走能力有关。胎龄≤27周、出生体重<1000 g、白人母亲以及存在高胆红素血症与独立行走显著相关。
