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肥胖对非骨水泥型全髋关节置换术中期生存率及临床结果的影响。

The effect of obesity on the mid-term survival and clinical outcome of cementless total hip replacement.

作者信息

Jackson M P, Sexton S A, Yeung E, Walter W L, Walter W K, Zicat B A

机构信息

Sydney Hip and Knee Surgeons, Sydney, New South Wales, Australia.

出版信息

J Bone Joint Surg Br. 2009 Oct;91(10):1296-300. doi: 10.1302/0301-620X.91B10.22544.

Abstract

The outcome of total hip replacement (THR) is potentially affected by the body mass index (BMI) of the patient. We studied the outcome of 2026 consecutive primary cementless THRs performed for osteoarthritis. The mean follow-up was 6.3 years (0 to 11.71) and no patient was lost to follow-up for survival analysis. The patients were divided into two groups according to their BMI as follows: non-obese (BMI < 30 kg/m(2)) and obese (BMI > or = 30 kg/m(2)). The obese patient undergoing surgery was found to be significantly younger (p < 0.001). The log-rank test for equality of survival showed no difference in the mid-term survival (p = 0.552) with an estimated survival at 11 years of 95.2% (95% CI 92.5 to 98.0) in the non-obese and 96.7% (95% CI 94.9 to 98.5) in the obese groups. The clinical and radiological outcome was determined in a case-matched study performed on 134 obese individuals closely matched with 134 non-obese controls. The non-obese group was found to have a significantly higher post-operative Harris hip score (p < 0.001) and an increased range of movement, but overall satisfaction with surgery was comparable with that of the obese patients. Radiological analysis of the acetabular and femoral components showed no significant differences with regard to radiolucent lines, osteolysis, ingrowth of the femoral component, the acetabular inclination angle or alignment of the femoral component. Our results suggest that the survival of cementless THR is not adversely affected by obesity. Obese patients can therefore be counselled that despite a lower clinical score, they should expect to be satisfied with the result of their THR with a mid-term survival rate equivalent to that of non-obese patients.

摘要

全髋关节置换术(THR)的结果可能会受到患者体重指数(BMI)的影响。我们研究了2026例因骨关节炎进行的连续初次非骨水泥型THR的结果。平均随访时间为6.3年(0至11.71年),且在生存分析中无患者失访。根据BMI将患者分为两组如下:非肥胖组(BMI < 30 kg/m²)和肥胖组(BMI≥30 kg/m²)。发现接受手术的肥胖患者明显更年轻(p < 0.001)。生存平等的对数秩检验显示中期生存率无差异(p = 0.552),非肥胖组11年的估计生存率为95.2%(95%可信区间92.5至98.0),肥胖组为96.7%(95%可信区间94.9至98.5)。在一项病例对照研究中,对134名肥胖个体和134名与之密切匹配的非肥胖对照者进行了临床和放射学结果的评估。发现非肥胖组术后Harris髋关节评分显著更高(p < 0.001),活动范围增加,但总体手术满意度与肥胖患者相当。髋臼和股骨假体的放射学分析显示,在透亮线、骨溶解、股骨假体生长、髋臼倾斜角度或股骨假体对线方面无显著差异。我们的结果表明,肥胖不会对非骨水泥型THR的生存率产生不利影响。因此,可以告知肥胖患者,尽管临床评分较低,但他们应预期对THR的结果感到满意,中期生存率与非肥胖患者相当。

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