Uchida Kenzo, Nakajima Hideaki, Yayama Takafumi, Sato Ryuichiro, Baba Hisatoshi
Department fo Orthopaedics Surgery, Faculty of Medical Sciences, University of Fukui.
Clin Calcium. 2009 Oct;19(10):1472-9.
Mechanisms of ossification processes, pathological changes, and treatment/assessment of myelopathy symptoms because of ossification of the posterior longitudinal ligament (OPLL) remain obscure. Enchondral ossification process of OPLL was closely associated with degenerative changes of elastic fibers and cartilage formation, together with the appearance of metaplastic hypertrophic cartilage cells and neovascularization. There are differences in expression degrees of cytokines and transcription factors between mixed and localized OPLL. While the chronic compressed spinal cord may have plasticity ; the use of stem cell implants, supplementation of neurotrophic factors, in addition to surgical treatment, may bring a better clinical outcome,encouraging the development of these basic research studies. Assessment using new imaging techniques needs to determine the affected level and judge the severity of symptoms.
后纵韧带骨化（OPLL）导致的骨化过程机制、病理变化以及脊髓病症状的治疗/评估仍不明确。OPLL的软骨内成骨过程与弹性纤维的退变、软骨形成密切相关，同时伴有化生的肥大软骨细胞和新血管形成。混合型和局限性OPLL之间细胞因子和转录因子的表达程度存在差异。虽然慢性受压的脊髓可能具有可塑性；除手术治疗外，使用干细胞植入、补充神经营养因子可能带来更好的临床结果，这鼓励了这些基础研究的开展。使用新的成像技术进行评估需要确定受累节段并判断症状的严重程度。
