与联会蛋白相关的精神分裂症患者的枕叶和前额叶脑容量减少。
Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia.
机构信息
Department of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland.
出版信息
Neuropsychopharmacology. 2010 Jan;35(2):368-73. doi: 10.1038/npp.2009.140.
Abstract
A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.
摘要
威廉姆斯等人（PMID：15066891）确定的三标记 C-A-T 神经结合蛋白单体型与精神分裂症风险增加、mRNA 表达减少、认知表现较差和早期感觉处理缺陷有关。我们研究了相同的神经结合蛋白单体型是否也与灰质体积（GMV）的结构变异有关。使用基于体素的形态计量学，全容积分析显示右侧背外侧前额叶和左侧枕叶皮质的 GMV 明显减少，这与已经报道的空间工作记忆受损的行为发现和视觉处理 EEG 发现受损相对应。这些数据提供了神经结合蛋白风险变异对大脑结构影响的重要证据，并表明了疾病风险增加的可能机制。
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