Chau J F L, Leong W F, Li B
The Institute of Molecular and Cell Biology, Singapore, Republic of Singapore.
Histol Histopathol. 2009 Dec;24(12):1593-606. doi: 10.14670/HH-24.1593.
Osteoblasts are bone forming cells that are responsible for bone growth and remodeling. They are derived from bone marrow mesenchymal stem cells through a series of processes including commitment, osteoprogenitor expansion, terminal differentiation and cell death. Osteoblastogenesis and bone formation are regulated by hormones, growth factors, cytokines, mechanical loading and aging. Osteoblasts can sense these external cues, transduce the signals through various signaling pathways and regulate the expression of specific genes, to determine the cell fate. In this review, we aim to update our current understanding of the signaling pathways that control different steps of osteoblast homeostasis, with special focus on how signaling events control cell fate through regulating gene expression.
成骨细胞是负责骨骼生长和重塑的骨形成细胞。它们通过一系列过程从骨髓间充质干细胞分化而来，这些过程包括定向分化、成骨祖细胞扩增、终末分化和细胞死亡。成骨细胞生成和骨形成受激素、生长因子、细胞因子、机械负荷和衰老的调节。成骨细胞能够感知这些外部信号，通过各种信号通路传导信号并调节特定基因的表达，从而决定细胞命运。在本综述中，我们旨在更新我们目前对控制成骨细胞稳态不同步骤的信号通路的理解，特别关注信号事件如何通过调节基因表达来控制细胞命运。
