Update: prostate cancer early detection clinical practice guidelines.

Histopathologic analysis of a biopsy specimen of the prostate, examined to ascertain the presence of malignancy, can result in 4 possible diagnostic scenarios: (1) prostate cancer, (2) no evidence of cancer, (3) high-grade prostatic intraepithelial neoplasia, and (4) atypical small-gland proliferation suggestive of malignancy but not diagnostic. Until new studies provide a better method for selecting patients to undergo rebiopsy, patients diagnosed with high-grade prostatic intraepithelial neoplasia from a single core biopsy should undergo rebiopsy. A diagnosis of atypical glands suggestive of malignancy indicates that a rebiopsy should be performed because the chances of finding an invasive carcinoma are high.