Novikova P Iu, Krasil'nikov P M
Biofizika. 2009 Jul-Aug;54(4):675-80.
The mutual arrangement of a phospholipid containing a peroxyl radical and the membrane antioxidant alpha-tocopherol (vitamin E) in the lipid bilayer has been studied using the method of molecular dynamics. The equilibrium states of the oxidized lipid and alpha-tocopherol in the membrane have been investigated. The mutual geometry of molecules in the membrane is revealed at which the hydrogen atom can be transferred from the hydroxyl group of alpha-tocopherol to the peroxyl radical of phospholipids. It is shown that, in equilibrium conditions, the peroxyl group of the oxidized lipid is located near the polar surface of the membrane, and alpha-tocopherol is embedded in the hydrophobic area of the lipid bilayer.
利用分子动力学方法研究了含有过氧自由基的磷脂与膜抗氧化剂α-生育酚（维生素E）在脂质双层中的相互排布。研究了膜中氧化脂质和α-生育酚的平衡态。揭示了膜中分子的相互几何结构，在此结构下氢原子可从α-生育酚的羟基转移至磷脂的过氧自由基上。结果表明，在平衡条件下，氧化脂质的过氧基团位于膜的极性表面附近，而α-生育酚嵌入脂质双层的疏水区域。
