脂肪酸对大鼠阿昔洛韦直肠吸收的影响。

The effect of fatty acids on the rectal absorption of acyclovir in rats.

作者信息

Yamazaki M, Itoh S, Sawanoi M, Kobayashi M, Suzuki S, Komatsu T, Tanabe K

机构信息

Faculty of Pharmaceutical Sciences, Osaka University, Japan.

出版信息

J Pharm Pharmacol. 1990 Jun;42(6):441-3. doi: 10.1111/j.2042-7158.1990.tb06589.x.

DOI:10.1111/j.2042-7158.1990.tb06589.x

PMID:1979629

Abstract

The enhancing effect of fatty acids on the rectal absorption of acyclovir has been evaluated in rats. Acyclovir proved to be absorbed to the extent of 3 to 9% after oral administration. After rectal administration in the absence of absorption-promoter, the bioavailability of acyclovir was 37%. Its rectal administration with 4% sodium caprate resulted in enhanced bioavailability (81 +/- 3%).

摘要

已经在大鼠中评估了脂肪酸对阿昔洛韦直肠吸收的增强作用。口服给药后，阿昔洛韦的吸收程度为3%至9%。在没有吸收促进剂的情况下直肠给药后，阿昔洛韦的生物利用度为37%。其与4%癸酸钠直肠给药导致生物利用度提高（81±3%）。