Department of Dermatology, Ege University Medical Faculty, Bornova-Izmir, Turkey.
Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S18-22.
Since Behçet's disease (BD) is a systemic vasculitis, it may deteriorate the quality of life of the patients. We aimed to investigate the relationship between the disease severity and the quality of life in patients with BD.
We studied 195 BD patients and 195 healthy controls who were matched with regard to age, gender and socio-economic status. Krause score was calculated to assess disease severity, while Short-form-36 (SF-36) and The World Health Organization Quality of Life (WHOQOL-100) were used to evaluate the quality of life in BD.
The overall SF-36 and WHOQOL-100 scale scores, as well as their domains were significantly lower in BD patients. In BD patients, "general health", "role-physical", domains of SF-36, and "psychological", "level of independence", "environment", "environmental-public" domains of WHOQOL-100 showed significantly negative linear correlations with Krause scores. In BD patients with arthritis, the scores of "general health", "physical functioning", "role emotional" domains of SF-36, and the scores of "psychological", "level of independence" and "social relations" domains of WHOQOL-100 were significantly worse than without arthritis. The scores of "pain" domain of SF-36 and "level of independence" domain of WHOQOL-100 were significantly worse in BD patients with vascular involvement, while the scores of "mental health" domain of SF-36 and "psychological" domain of WHOQOL-100 were significantly worse in BD patients with eye involvement.
Based on the evaluation of SF-36 and WHOQOL-100 scores, quality of life is impaired and related with disease severity in BD. Arthritis, eye involvement and vascular involvement seem to contribute to this impairment.
由于白塞病（BD）是一种系统性血管炎，它可能会降低患者的生活质量。我们旨在研究 BD 患者疾病严重程度与生活质量之间的关系。
我们研究了 195 例 BD 患者和 195 例年龄、性别和社会经济状况相匹配的健康对照者。采用 Krause 评分评估疾病严重程度，采用短表-36（SF-36）和世界卫生组织生活质量（WHOQOL-100）评估 BD 患者的生活质量。
BD 患者的总体 SF-36 和 WHOQOL-100 量表评分及其各领域评分均显著降低。在 BD 患者中，SF-36 的“一般健康状况”、“生理职能”以及 WHOQOL-100 的“心理”、“独立性”、“环境”和“环境-公共”领域与 Krause 评分呈显著负线性相关。在有关节炎的 BD 患者中，SF-36 的“一般健康状况”、“生理机能”、“生理职能”以及 WHOQOL-100 的“心理”、“独立性”和“社会关系”领域的评分明显差于无关节炎的患者。BD 患者有血管病变时，SF-36 的“疼痛”领域和 WHOQOL-100 的“独立性”领域的评分明显较差，而 BD 患者有眼部病变时，SF-36 的“心理健康”领域和 WHOQOL-100 的“心理”领域的评分明显较差。
根据 SF-36 和 WHOQOL-100 评分评估，BD 患者的生活质量受损且与疾病严重程度相关。关节炎、眼部病变和血管病变似乎对此有影响。
