Zhang Huan, Ju Zhong, Xu Tan, Tong Weijun, Jin Erdunchaolu, Wang Ning, Zhang Yonghong
Department of Epidemiology, Medical College of Sochow University, Suzhou, China.
Clin Invest Med. 2009 Oct 1;32(5):E307-13. doi: 10.25011/cim.v32i5.6917.
To study the association between blood pressure (BP) SBP, DBP, mean arterial pressure (MAP) and pulse pressure (PP) and clinical outcome in acute hemorrhagic stroke patients in the Chinese population.
1,760 hemorrhagic stroke patients admitted to six hospitals from January 1, 2003 to December 31, 2005 were included in the study. BP and other variables were collected within the first 24-hr of admission. Clinical outcomes at discharge were evaluated by neurologists. Multivariate-adjusted odds ratios associated with increment of 1 standard deviation (SD) mmHg in four BP were determined by multiple logistic regression analysis.
The four BP indexes at admission were positively associated with death and SBP, DBP, MAP were associated with dependency. Adjusted odds ratios (95% confident interval) of death associated with increment of 1 SD mmHg were 1.74 (1.44,2.12), 1.39 (1.15,1.69),1.61 (1.32,1.96) and 1.66 (1.39,1.99) for SBP, DBP, MAP and PP, respectively (all P < 0.01), and adjusted odds ratio of dependency associated with increment of 1 SD mmHg was 1.15 (1.03,1.27), 1.21 (1.09,1.34) and 1.19 (1.07,1.32) for SBP, DBP and MAP, respectively (all P < 0.05).
Increased SBP, DBP, MAP and PP at admission were all associated with in-hospital mortality, and increased SBP, DBP and MAP were associated with dependency at discharge among hemorrhagic stroke patients.
研究中国人群急性出血性卒中患者的血压(BP)收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)和脉压(PP)与临床结局之间的关联。
纳入2003年1月1日至2005年12月31日期间在6家医院住院的1760例出血性卒中患者。在入院后的头24小时内收集血压及其他变量。出院时的临床结局由神经科医生评估。通过多因素逻辑回归分析确定与四种血压每增加1个标准差(SD)mmHg相关的多因素调整比值比。
入院时的四项血压指标与死亡呈正相关,SBP、DBP、MAP与依赖相关。SBP、DBP、MAP和PP每增加1个SD mmHg与死亡相关的调整比值比(95%置信区间)分别为1.74(1.44,2.12)、1.39(1.15,1.69)、1.61(1.32,1.96)和1.66(1.39,1.99)(均P<0.01),SBP、DBP和MAP每增加1个SD mmHg与依赖相关的调整比值比分别为1.15(1.03,1.27)、1.21(1.09,1.34)和1.19(1.07,1.32)(均P<0.05)。
出血性卒中患者入院时SBP、DBP、MAP和PP升高均与院内死亡率相关,SBP、DBP和MAP升高与出院时的依赖相关。