Aroian R V, Koga M, Mendel J E, Ohshima Y, Sternberg P W
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125.
Nature. 1990;348(6303):693-9. doi: 10.1038/348693a0.
The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.
let-23基因是秀丽隐杆线虫外阴诱导所必需的。研究表明，let-23编码一种表皮生长因子受体亚家族的假定酪氨酸激酶。因此，let-23可能编码外阴发育所需诱导信号的受体。由于let-23在对外阴决定途径中位于let-60 ras的上游，let-23产物的鉴定为细胞类型决定途径中酪氨酸激酶生长因子受体和ras蛋白之间的体内联系提供了支持。
