Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Jiangsu Changzhou, China.
Acta Histochem. 2011 Jan;113(1):53-7. doi: 10.1016/j.acthis.2009.08.005. Epub 2009 Oct 1.
The present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in the adjacent tissues. Plasma apoM levels in these HCC patients were also determined and compared to the normal subjects. The mean level of plasma apoM in the HCC patients was 0.61±0.30ODmm⁻², which was significantly higher than that in the normal subjects 0.37±0.07ODmm⁻² (P<0.01). However, both apoM mRNA levels and apoM protein mass in the HCC tissues were significantly lower than in the adjacent tissues (P<0.05). It is concluded that human hepatocellular carcinoma tissues had a reduced capacity to produce apoM than the adjacent non-tumor tissues. However, the plasma apoM levels were higher in the HCC patients than in normal subjects, which suggested that tissues adjacent to the tumors or extra-hepatic apoM production in the HCC patients may contribute to the higher plasma apoM levels in these patients. The clinical significance of apoM in relation to HCC still needs further investigation.
本研究检测了人肝癌（HCC）组织及其相邻组织中的载脂蛋白 M（apoM）mRNA 水平和蛋白质量，同时还测定了这些 HCC 患者的血浆 apoM 水平并与正常对照者进行了比较。HCC 患者的平均血浆 apoM 水平为 0.61±0.30ODmm⁻²，明显高于正常对照者的 0.37±0.07ODmm⁻²（P<0.01）。然而，HCC 组织中的 apoM mRNA 水平和 apoM 蛋白质量均明显低于相邻组织（P<0.05）。由此得出结论，与相邻非肿瘤组织相比，人肝癌组织产生 apoM 的能力降低。然而，HCC 患者的血浆 apoM 水平高于正常对照者，这表明肿瘤旁组织或 HCC 患者的肝外 apoM 产生可能导致这些患者的血浆 apoM 水平升高。apoM 与 HCC 的临床意义仍需进一步研究。
