临床研究中的事件相关电位：诱发、记录和量化失配负波、P300和N400的指南。

Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400.

作者信息

Duncan Connie C, Barry Robert J, Connolly John F, Fischer Catherine, Michie Patricia T, Näätänen Risto, Polich John, Reinvang Ivar, Van Petten Cyma

机构信息

Clinical Psychophysiology and Psychopharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

School of Psychology and Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia.

出版信息

Clin Neurophysiol. 2009 Nov;120(11):1883-1908. doi: 10.1016/j.clinph.2009.07.045. Epub 2009 Sep 30.

DOI:10.1016/j.clinph.2009.07.045

PMID:19796989

Abstract

This paper describes recommended methods for the use of event-related brain potentials (ERPs) in clinical research and reviews applications to a variety of psychiatric and neurological disorders. Techniques are presented for eliciting, recording, and quantifying three major cognitive components with confirmed clinical utility: mismatch negativity (MMN), P300, and N400. Also highlighted are applications of each of the components as methods of investigating central nervous system pathology. The guidelines are intended to assist investigators who use ERPs in clinical research, in an effort to provide clear and concise recommendations and thereby to standardize methodology and facilitate comparability of data across laboratories.

摘要

本文介绍了在临床研究中使用事件相关脑电位（ERP）的推荐方法，并综述了其在各种精神和神经疾病中的应用。文中展示了用于诱发、记录和量化具有临床实用价值的三个主要认知成分的技术：失配负波（MMN）、P300和N400。还强调了每个成分作为研究中枢神经系统病理学方法的应用。这些指南旨在帮助在临床研究中使用ERP的研究人员，努力提供清晰简洁的建议，从而规范方法并促进不同实验室数据的可比性。