黄体期给予促性腺激素释放激素激动剂对卵胞浆内单精子注射后着床率的有益作用。
Beneficial effect of luteal-phase gonadotropin-releasing hormone agonist administration on implantation rate after intracytoplasmic sperm injection.
作者信息
Razieh Dehghani Firouzabadi, Maryam Ayazi Rozbahani, Nasim Tabibnejad
机构信息
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
Taiwan J Obstet Gynecol. 2009 Sep;48(3):245-8. doi: 10.1016/S1028-4559(09)60297-7.
OBJECTIVE
To evaluate the effect of gonadotropin-releasing hormone (GnRH) agonist, administered in the luteal phase, on intracytoplasmic sperm injection (ICSI) outcome.
MATERIALS AND METHODS
One hundred and eighty women undergoing ovarian stimulation for ICSI were enrolled in this study. Patients were randomly assigned to receive a single dose of GnRH agonist or placebo. Implantation rate and clinical pregnancy rate were the main outcomes.
RESULTS
Administration of 0.1 mg of the GnRH agonist triptorelin on day 3 after embryo transfer led to a significant improvement in implantation rate (12.3% vs. 7.3%) and clinical pregnancy rate (25.5% vs. 10.0%) as compared with placebo.
CONCLUSION
Luteal phase GnRH agonist administration enhances ICSI clinical outcomes.
目的
评估在黄体期给予促性腺激素释放激素（GnRH）激动剂对卵胞浆内单精子注射（ICSI）结局的影响。
材料与方法
本研究纳入了180例接受卵巢刺激以进行ICSI的女性。患者被随机分配接受单剂量的GnRH激动剂或安慰剂。种植率和临床妊娠率为主要观察指标。
结果
与安慰剂相比，在胚胎移植后第3天给予0.1mg的GnRH激动剂曲普瑞林可使种植率（12.3%对7.3%）和临床妊娠率（25.5%对10.0%）显著提高。
结论
黄体期给予GnRH激动剂可改善ICSI的临床结局。
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