Isikoglu Mete, Ozgur Kemal, Oehninger Sergio
Antalya IVF, Antalya, Turkey.
J Reprod Med. 2007 Jul;52(7):639-44.
To investigate the effect of continuous administration of gonadotropin-releasing hormone agonist (GnRHa) during the luteal phase in an intracytoplasmic sperm injection program.
One hundred eighty-one women underwent a down-regulation protocol of GnRHa administered from the 21st day of the preceding cycle. Patients were randomized at initiation of stimulation by a computer-generated list. Group 1 patients (n = 90) were continuously administered GnRHa for 12 days after embryo transfer, while in group 2 patients GnRHa was stopped on the day of human chorionic gonadotropin administration.
Demographic parameters, infertility etiologies, number of gonadotropin ampules used, number of mature oocytes recovered, rates of testicular sperm usage, number of embryos transferred, and cycle and transfer cancellation rates were similar in both groups. Clinical pregnancy rates, implantation rates and live birth rates did not show a significant difference.
Extending GnRHa treatment through the luteal phase appeared not to have a significant impact on pregnancy or implantation rates in intracytoplasmic sperm injection cycles.
探讨在卵胞浆内单精子注射（ICSI）程序中，黄体期持续应用促性腺激素释放激素激动剂（GnRHa）的效果。
181名女性在前一周期的第21天开始接受GnRHa的降调节方案。在开始刺激时，通过计算机生成的列表将患者随机分组。第1组患者（n = 90）在胚胎移植后连续应用GnRHa 12天，而第2组患者在注射人绒毛膜促性腺激素当天停用GnRHa。
两组患者的人口统计学参数、不孕病因、促性腺激素安瓿使用数量、回收的成熟卵母细胞数量、睾丸精子使用率、移植胚胎数量以及周期取消率和移植取消率相似。临床妊娠率、着床率和活产率均无显著差异。
在黄体期延长GnRHa治疗似乎对卵胞浆内单精子注射周期的妊娠率或着床率没有显著影响。
