腺样体扁桃体肥大的儿童的 IGF-1 和 ghrelin 水平是否低于正常儿童？
Do children with adenotonsillar hypertrophy have lower IGF-1 and ghrelin levels than the normal children?
出版信息
J Trop Pediatr. 2010 Jun;56(3):213-5. doi: 10.1093/tropej/fmp093. Epub 2009 Oct 1.
OBJECTIVE
This study was designed to determine serum insulin-like growth factor-1 (IGF-1) and plasma ghrelin levels in male children with adenoid and tonsillar hypertrophy and compare them with healthy controls.
METHODS
This study included 29 male prepubertal children between the ages of 6.5 and 10 years (mean age 8.8 +/- 2.5 years) with obstructive adenoid and tonsillar hypertrophy and 20 normal male controls between the ages of 5.7 and 10.8 years (mean age 8.2 +/- 2.9 years). Plasma ghrelin and serum IGF-1 levels were measured at 8.30, in the morning.
RESULTS
Children with adenoid and tonsillar hypertrophy had significantly depressed serum IGF-1 levels (203 +/- 150 ng ml(-1)) and plasma ghrelin levels (175 +/- 66 pg ml(-1)) compared with healthy controls (354 +/- 242 ng ml(-1) and 243 +/- 93 pg ml(-1), respectively, P < 0.05).
CONCLUSION
Depressed levels of ghrelin in children with adenoid and tonsillar hypertrophy lead to decreased appetite and insufficient energy intake. Lower serum levels of IGF-1 in children with adenoid and tonsillar hypertrophy may be secondary to deficient growth hormone stimulation by ghrelin.
目的
本研究旨在测定腺样体和扁桃体肥大男童的血清胰岛素样生长因子-1（IGF-1）和血浆 ghrelin 水平，并与健康对照组进行比较。
方法
本研究纳入了 29 名年龄在 6.5 至 10 岁（平均年龄 8.8±2.5 岁）的有阻塞性腺样体和扁桃体肥大的男性青春期前儿童，以及 20 名年龄在 5.7 至 10.8 岁（平均年龄 8.2±2.9 岁）的正常男性对照。于上午 8:30 测量血浆 ghrelin 和血清 IGF-1 水平。
结果
与健康对照组相比，腺样体和扁桃体肥大儿童的血清 IGF-1 水平（203±150ng/ml）和血浆 ghrelin 水平（175±66pg/ml）显著降低（分别为 354±242ng/ml 和 243±93pg/ml，P<0.05）。
结论
腺样体和扁桃体肥大儿童中 ghrelin 水平降低导致食欲下降和能量摄入不足。腺样体和扁桃体肥大儿童血清 IGF-1 水平降低可能是 ghrelin 对生长激素刺激不足所致。
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