睡眠呼吸障碍儿童腺样体扁桃体切除术后胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子结合蛋白-3（IGFBP-3）和胃饥饿素水平的变化
Changes in IGF-I, IGFBP-3 and ghrelin levels after adenotonsillectomy in children with sleep disordered breathing.
作者信息
Gümüssoy Murat, Atmaca Sinan, Bilgici Birsen, Unal Recep
机构信息
Dept of Otolaryngology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
出版信息
Int J Pediatr Otorhinolaryngol. 2009 Dec;73(12):1653-6. doi: 10.1016/j.ijporl.2009.08.025. Epub 2009 Sep 18.
OBJECTIVE
The aim of this study was to determine the changes in insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels following adenotonsillectomy (T&A) in children with sleep disordered breathing (SDB).
METHODS
Forty children (mean age 4.85+/-2.15 years) clinically diagnosed with adenotonsillar hypertrophy (ATH) related SDB were enrolled. All children underwent T&A. Serum levels of IGF-I, IGFBP-3 and ghrelin were measured before and 6 months after T&A.
RESULTS
Serum levels of IGF-I and IGFBP-3 were significantly higher after T&A (p<0.001). Serum ghrelin levels showed a significant decrease after T&A (p<0.001).
CONCLUSION
Children with ATH related SDB who underwent T&A showed significant increases in IGF-I and IGFBP-3 levels indicating an increase in diurnal growth hormone secretion as well as a significant decrese in ghrelin levels indicating an increased oral food intake in the postoperative period.
目的
本研究旨在确定睡眠呼吸障碍（SDB）患儿行腺样体扁桃体切除术（T&A）后胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子结合蛋白-3（IGFBP-3）和胃饥饿素水平的变化。
方法
纳入40例临床诊断为腺样体扁桃体肥大（ATH）相关SDB的儿童（平均年龄4.85±2.15岁）。所有儿童均接受T&A手术。在T&A术前及术后6个月测量血清IGF-I、IGFBP-3和胃饥饿素水平。
结果
T&A术后血清IGF-I和IGFBP-3水平显著升高（p<0.001）。T&A术后血清胃饥饿素水平显著降低（p<0.001）。
结论
行T&A手术的ATH相关SDB患儿术后IGF-I和IGFBP-3水平显著升高，表明日间生长激素分泌增加，同时胃饥饿素水平显著降低，表明术后口腔食物摄入量增加。
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