Esensten Jonathan H, Wofsy David, Bluestone Jeffrey A
Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Nat Rev Rheumatol. 2009 Oct;5(10):560-5. doi: 10.1038/nrrheum.2009.183.
Regulatory T cells (TREG) are a subset of CD4+ T cells with a critical role in the prevention of autoimmunity. Whether defects in TREG contribute to the pathogenesis of rheumatoid arthritis (RA) is unclear. However, a variety of approved and experimental drugs for RA may work, in part, by promoting the function or increasing numbers of TREG. Furthermore, animal studies demonstrate that direct injection of TREG ameliorates a wide range of experimental models of inflammatory and autoimmune diseases. Thus, cell-based therapy with TREG has the potential to produce durable disease remission in patients with RA.
调节性T细胞(TREG)是CD4 + T细胞的一个亚群,在预防自身免疫中起关键作用。TREG缺陷是否导致类风湿性关节炎(RA)的发病机制尚不清楚。然而,多种已批准的和用于RA的实验性药物可能部分通过促进TREG的功能或增加其数量而起作用。此外,动物研究表明,直接注射TREG可改善多种炎症和自身免疫性疾病的实验模型。因此,基于TREG的细胞疗法有可能使RA患者实现持久的疾病缓解。