Wang Wen-Kui, Han Li-Zhong, Yang Li, Ni Yu-Xing
Department of Burns and Plastic Surgery, Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, China.
Zhonghua Shao Shang Za Zhi. 2009 Apr;25(2):94-7.
To analyse the distribution, drug resistance and epidemiology of pathogenic bacteria in the burn wards of Ruijin Hospital.
Seventeen strains of Methicillin resistant staphylococcus aureus (MRSA), 52 strains of Pseudomonas aeruginosa (PA), and 11 strains of Acinetobacter baumannii (AB) isolated from the wound secretion, venous catheters, blood, urine and stool etc. were collected from burn patients hospitalized in our department from January 2004 to December 2006. The distribution and the drug resistance profile of bacteria were analyzed, and the homology analysis was performed by randomly amplified polymorphic DNA (RAPD).
MRSA, PA and AB were the major strains in our burn wards in recent years, of which Staphylococcus aureus (SA) was the most dominant. During these 3 years, MRSA accounted for 77% (63/82), 85% (63/74), and 75% (74/99), respectively, for SA isolated in this period. MRSA was resistant to Amikacin, Gentamicin, Erythromycin, Clindamycin and Levofloxacin; PA was resistant to Amikacin, Gentamicin, Piperacillin, Ceftazidime, Cefoperazone, Aztreonam and Imipenem; AB was resistant to Amikacin, Gentamicin, Piperacillin, Ceftazidime, Imipenem and Ciprofloxacin. Three bacteria were found to belong to the same type in the RAPD homology analysis.
There are many kind of multi-drug resistant pathogenic bacteria for nosocomial infection in our burn wards. To control the spread of infection due to above-mentioned 3 bacteria is the focus of nosocomial infection control.
分析瑞金医院烧伤病房病原菌的分布、耐药性及流行病学特征。
收集2004年1月至2006年12月在我科住院的烧伤患者伤口分泌物、静脉导管、血液、尿液及粪便等标本中分离出的17株耐甲氧西林金黄色葡萄球菌（MRSA）、52株铜绿假单胞菌（PA）和11株鲍曼不动杆菌（AB）。分析细菌的分布及耐药谱，并采用随机扩增多态性DNA（RAPD）进行同源性分析。
MRSA、PA和AB是近年来我院烧伤病房的主要病原菌，其中金黄色葡萄球菌（SA）最为常见。在这3年中，MRSA分别占同期分离出的SA的77%（63/82）、85%（63/74）和75%（74/99）。MRSA对阿米卡星、庆大霉素、红霉素、克林霉素和左氧氟沙星耐药；PA对阿米卡星、庆大霉素、哌拉西林、头孢他啶、头孢哌酮、氨曲南和亚胺培南耐药；AB对阿米卡星、庆大霉素、哌拉西林、头孢他啶、亚胺培南和环丙沙星耐药。RAPD同源性分析发现3种细菌属于同一类型。
我院烧伤病房医院感染的病原菌中多耐药菌种类较多。控制上述3种细菌引起的感染传播是医院感染控制的重点。
