[支气管镜下肺减容药物的实验研究]
[An experimental study of bronchoscopic lung volume reduction medicine].
作者信息
Zhou Li-yan, Wang Ping, Wang Rui-juan, Zhou Jin-lian, Liu Si-hua
机构信息
Department of Respiratory, 306th Hospital of People's Liberation Army, Beijing 100101, China.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 2009 May;32(5):373-6.
OBJECTIVE
To evaluate the effect and safety of experimental bronchoscopic lung volume reduction (BLVR) using an one-way valve designed independently.
METHODS
The animal study was carried out from June to December 2008. Totally 36 valves were implanted in the target bronchi of 12 healthy male goats. CT scan, artery blood gas exchange and lung pathology were performed after 2, 4, 8 and 12 weeks.
RESULTS
All the valves were implanted successfully, but 3 valves were expectorated at the end. The procedure was well tolerated. CT scan showed that for more than 45% (15/33) of the valves, the target lung tissue had collapsed. Lung pathology showed that the alveolar space was deflated and collapsed. Lymphocytes and monocytes infiltrated the interstitial tissue with some degree of fibrosis.
CONCLUSIONS
This animal study showed that the independently manufactured one way valve was effective and safe. The one way valve may be useful in the treatment of severe emphysema in the future.
目的
评估使用自主设计的单向阀进行实验性支气管镜肺减容术（BLVR）的效果及安全性。
方法
动物研究于2008年6月至12月进行。将总共36个阀门植入12只健康雄性山羊的目标支气管中。在2周、4周、8周和12周后进行CT扫描、动脉血气交换及肺病理检查。
结果
所有阀门均成功植入，但最后有3个阀门被咳出。该操作耐受性良好。CT扫描显示，超过45%（15/33）的阀门使目标肺组织出现塌陷。肺病理显示肺泡腔瘪陷、塌陷。淋巴细胞和单核细胞浸润间质组织，伴有一定程度的纤维化。
结论
该动物研究表明，自主制造的单向阀有效且安全。该单向阀未来可能对重度肺气肿的治疗有用。
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