Niu Rui, Shao Ming-ju, Liu Bo, Huang Xiao-chun, Che Xiao-wen, Wang Wei
Department of Respiratory, Second Hospital of Shandong University, Jinan 250033, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 May;30(5):511-3.
To study the morbidity of cough variant asthma (CVA) among patients with chronic cough syndrome and its relative risk factors.
Patients were recruited with detailed history on their illness. Data were collected on physical examination, chest X-ray, eosinophil cell counts, pulmonary ventilation with histamine stimulating test and bronchi dilation test. According to available data, diagnosis of CVA was confirmed and the relative factors Questionnaire form was completed for each patient.
Among 473 patients with chronic cough, 95 (44 male and 51 female) were confirmed to be CVA (20.08%). Analysis of the relative factors suggested that CVA was associated with multiple factors. Morbidity of CVA was associated with season, personal histories on allergy and family history on asthma. CVA could be induced by upper respiratory tract infection, inhale of oil vapor, acrimony air, over-burdened physical exercises etc.
For patients with chronic cough symptom, clear diagnosis of CVA, avoid of passable risk factors and timely medical intervention when necessary, would be helpful in controlling clinical courses and improving the prognosis of the disease.
研究慢性咳嗽综合征患者中咳嗽变异性哮喘（CVA）的发病率及其相关危险因素。
招募有详细病史的患者。收集体格检查、胸部X线、嗜酸性粒细胞计数、组胺激发试验肺通气功能及支气管舒张试验的数据。根据现有数据确诊CVA，并为每位患者填写相关因素问卷表。
在473例慢性咳嗽患者中，95例（男性44例，女性51例）确诊为CVA（20.08%）。对相关因素的分析表明，CVA与多种因素有关。CVA的发病率与季节、个人过敏史和哮喘家族史有关。上呼吸道感染、吸入油烟、刺激性空气、过度劳累的体育锻炼等可诱发CVA。
对于有慢性咳嗽症状的患者，明确诊断CVA，避免可能的危险因素，必要时及时进行医学干预，有助于控制临床病程，改善疾病预后。
