Yeomans Neville D
School of Medicine, University of Western Sydney, Penrith South DC, New South Wales, Australia.
J Gastroenterol Hepatol. 2009 Oct;24 Suppl 3:S2-4. doi: 10.1111/j.1440-1746.2009.06064.x.
There have been numerous and dramatic advances in our understanding of the mechanisms, causes and treatments of upper gastrointestinal diseases in the past 50 years. This review focuses on a few, not dealt with elsewhere in this special issue of the Journal. The early history of the recognition that nonsteroidal anti-inflammatory drugs are a major cause of peptic ulcer is described, with particular attention to the work of the pioneering Australian investigators. The story of the development of the histamine H(2)-receptor antagonists and the proton pump inhibitors is also outlined.
在过去50年里，我们对上消化道疾病的机制、病因及治疗的理解取得了众多重大进展。本综述聚焦于其中一些内容，本刊这一特刊的其他地方未作讨论。文中描述了非甾体抗炎药是消化性溃疡主要病因这一认识的早期历史，特别关注了澳大利亚先驱研究者的工作。还概述了组胺H2受体拮抗剂和质子泵抑制剂的研发历程。
