Larson C P, Shuer L M, Cohen S E
Department of Anesthesia, Stanford University School of Medicine, CA 94305.
J Clin Anesth. 1990 Nov-Dec;2(6):427-9. doi: 10.1016/0952-8180(90)90031-w.
Fetal heart rate was monitored during the administration of esmolol 100 micrograms/kg/min to a 36-year-old, 29-week pregnant woman who was undergoing craniotomy for surgical treatment of six cerebral aneurysms. During stable general anesthesia, sodium nitroprusside was administered to induce moderate hypotension; at the same time, esmolol was infused to control maternal tachycardia. Within minutes after starting the esmolol infusion, maternal heart rate decreased from 100 beats/minute to 65 beats/minute, and fetal heart rate decreased from 160 beats/minute to 130 beats/minute. Upon termination of the infusion 3 hours later, both maternal and fetal heart rate returned to preinfusion values. No adverse effects of esmolol infusion were noted in the mother or fetus.
在给一名36岁、孕29周的孕妇静脉输注艾司洛尔（100微克/千克/分钟）期间监测胎儿心率，该孕妇正在接受开颅手术以治疗6个脑动脉瘤。在稳定的全身麻醉期间，给予硝普钠以诱导中度低血压；同时，输注艾司洛尔以控制产妇心动过速。在开始输注艾司洛尔后的几分钟内，产妇心率从100次/分钟降至65次/分钟，胎儿心率从160次/分钟降至130次/分钟。3小时后输注结束时，产妇和胎儿心率均恢复到输注前的值。未观察到艾司洛尔输注对母亲或胎儿有不良影响。
