Kollind M, Moberg E, Lins P E, Adamson U
Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden.
Horm Metab Res. 1990 Nov;22(11):581-3. doi: 10.1055/s-2007-1004978.
The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i.v. insulin substitution for 18 hours. A constant rate i.v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 micrograms/h) and 180-240 min (250 micrograms/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P less than 0.05) as well as in the high dose (P less than 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion.
在8例胰岛素依赖型糖尿病（IDDM）患者中研究了循环生长抑素对胰岛素水平的影响。该研究在患者过夜禁食后进行，此时他们皮下储存的胰岛素在静脉内胰岛素替代18小时期间已被耗尽。以恒定速率静脉输注胰岛素（0.4 mU/kg/分钟）240分钟，生长抑素分别在60 - 120分钟（100微克/小时）和180 - 240分钟（250微克/小时）期间共同输注。每隔15分钟测量血浆胰岛素、血糖和血细胞比容。在研究期间，血细胞比容从41.7%降至38.3%。生长抑素在低剂量期（P < 0.05）和高剂量期（P < 0.05）均使校正血细胞比容变化后的血浆胰岛素水平升高约8%。结论是，生长抑素干扰胰岛素的清除，从而增加无残余胰岛素分泌的IDDM患者的循环血浆胰岛素水平。
