Hoffstedt B, Walder M
Department of Infectious Diseases, University of Lund, General Hospital, S-214 01 Malmö, Sweden.
J Antimicrob Chemother. 1981 Sep;8 Suppl B:289-92. doi: 10.1093/jac/8.suppl_b.289.
Eight patients were treated with ceftazidime, four of whom had impaired renal function with creatinine clearances below 60 ml/min per 1.73 m2. The levels of ceftazidime in serum and extracellular fluid were determined. Half-life in serum and extracellular fluid was 2.5 and 2.2 h respectively for patients with normal renal function. For patients with impaired renal function the half-life of the drug was 7.9 and 115 h, respectively. The penetration of ceftazidime into extracellular fluid was around 50% in both groups. The levels achieved in both serum and extracellular fluid were satisfactorily high and prolonged, suggesting that a dosage regimen of 1 g twice daily is satisfactory.
8例患者接受了头孢他啶治疗，其中4例肾功能受损，肌酐清除率低于60 ml/（min·1.73 m²）。测定了血清和细胞外液中头孢他啶的水平。肾功能正常的患者血清和细胞外液中的半衰期分别为2.5小时和2.2小时。肾功能受损的患者药物半衰期分别为7.9小时和115小时。两组中头孢他啶进入细胞外液的渗透率均约为50%。血清和细胞外液中达到的水平均令人满意地高且持续时间长，这表明每日两次1 g的给药方案是令人满意的。
