Du Yu-Qing, Hori S, Zhou Wei-Zhong, Liu Yong-E
Department of Interventional Radiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2009 May;25(3):193-6.
To determine the effect, safety, and feasibility of embolization of high flow arteriovenous malformations (AVMs) with HepaSphere microspheres.
HepaSphere particles swell by absorbing fluids and become soft and deformable with a precisely calibrated diameter. 13 patients with AVMs were treated by transarterial embolization with HepaSphere particles. 3 cases underwent a following AVMs resection surgery. The follow-up period was 3 months to 3 years. Symptoms improvement and image examination were studied.
28 transarterial embolizations were performed in 13 cases. The resection operation was performed in 3 cases after transarterial embolizations. The symptoms in diffused AVMs improved after several transarterial embolizations. Histologically, HepaSphere particles penetrated into the intralesional vessels and conformed to the vessel lumen, resulting in vessel occlusion. Minimal perivascular reaction was observed.
Embolization of high flow AVMs with HepaSphere microspheres is safe and effective. Combined treatment is necessary for diffuse AVMs.
确定使用肝球微球栓塞高流量动静脉畸形（AVM）的效果、安全性和可行性。
肝球颗粒通过吸收液体膨胀，变得柔软且可变形，直径经过精确校准。13例AVM患者接受了经动脉肝球颗粒栓塞治疗。3例随后接受了AVM切除术。随访期为3个月至3年。研究症状改善情况和影像学检查结果。
13例患者共进行了28次经动脉栓塞。3例在经动脉栓塞后进行了切除手术。多次经动脉栓塞后，弥漫性AVM的症状有所改善。组织学检查显示，肝球颗粒进入病变内血管并与血管腔贴合，导致血管闭塞。观察到最小的血管周围反应。
使用肝球微球栓塞高流量AVM是安全有效的。弥漫性AVM需要联合治疗。
