Sidel'nikov Iu N, Sivoraksha G A
Urol Nefrol (Mosk). 1990 Jul-Aug(4):46-8.
In order to explore possible involvement of histamine and serotonin in acute renal failure related to hemorrhagic fever with renal syndrome (HFRS), selected markers or renal lesions have been compared with biochemical findings in highly severe cases. Literature reports and the study results lead the authors to conclude that histamine and serotonin are obviously pathogenetic determinants of HFRS since their concentrations in plasma of these patients are increased 3-fold. It is suggested that the biologically active substances may be a link between renal disease and hyperergy in severe and critical disease forms.
为探讨组胺和5-羟色胺在肾综合征出血热（HFRS）相关急性肾衰竭中可能的作用，将所选的肾损伤标志物与重症病例的生化检查结果进行了比较。文献报道和研究结果使作者得出结论，组胺和5-羟色胺显然是HFRS的致病决定因素，因为这些患者血浆中它们的浓度增加了3倍。提示这些生物活性物质可能是重症和危重症疾病形式下肾脏疾病与超敏反应之间的联系。
