区域小鼠脑生物胺、酸性代谢产物及运动活动的行为遗传学分析。

Behavioral genetic analysis of regional mouse brain biogenic amines, acidic metabolites and motor activity.

Messiha F S

Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(2):389-92. doi: 10.1016/0742-8413(90)90027-7.

Abstract

Comparative analyses of regional brain biogenic amines and spontaneous locomotor activity of three mouse strains suggest a genotype dependent relationship. 2. A positive correlation between striatal dopamine and locomotor activity was determined in the inbred albino BALB/c mouse strain. 3. An inverse relationship between some brain regions serotonin and motility was found in the inbred black C57BL/6 mouse strain. 4. No correlation could be established between brain monoamines and motor activity in the hybrid CDF-1 mouse strain. 5. The results suggest that inbred BALB/c and C57BL/6 mouse strains may be useful animal models for studying dopaminergic and serotonergic acting agents, respectively.

摘要

对三种小鼠品系的区域性脑内生物胺和自发运动活性进行的比较分析表明存在基因型依赖性关系。2. 在近交白化BALB/c小鼠品系中，纹状体多巴胺与运动活性之间呈正相关。3. 在近交黑色C57BL/6小鼠品系中，发现某些脑区血清素与运动性之间呈负相关。4. 在杂种CDF-1小鼠品系中，脑单胺与运动活性之间无法建立相关性。5. 结果表明，近交BALB/c和C57BL/6小鼠品系可能分别是用于研究多巴胺能和5-羟色胺能作用剂的有用动物模型。