Gosselin A M, Biro G P
Department of Physiology, University of Ottawa, Ontario, Canada.
Angiology. 1990 Dec;41(12):1058-64. doi: 10.1177/000331979004101206.
The effects of low-dose (10(-9) and 3 x 10(-9) mole/kg/min) infusions of dopexamine HCl, a new synthetic catecholamine with beta 2-adrenergic and DA1-dopaminergic agonostic actions, was tested in anesthetized dogs, with and without acute ligation of the left anterior descending coronary artery. The infusions caused diastolic arterial blood pressure to fall by 12 +/- 4 and 23 +/- 5 mmHg, respectively. Microsphere-estimated collateral blood flow to the ischemic myocardium did not change significantly during the drug infusions. The findings suggest that low doses of dopexamine HCl do not cause coronary "steal" from acutely ischemic myocardium.
对盐酸多培沙明（一种具有β₂-肾上腺素能和DA₁-多巴胺能激动作用的新型合成儿茶酚胺）进行低剂量（10⁻⁹和3×10⁻⁹摩尔/千克/分钟）输注，在有和没有急性结扎左前降支冠状动脉的麻醉犬中测试其效果。输注分别使舒张压下降12±4和23±5毫米汞柱。在药物输注期间，用微球估计的缺血心肌侧支血流量没有显著变化。这些发现表明，低剂量的盐酸多培沙明不会导致急性缺血心肌的冠状动脉“窃血”。
