Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9 rue Edward Steichen, 2540 Luxembourg, Luxembourg.
Genes Nutr. 2010 Mar;5(1):61-74. doi: 10.1007/s12263-009-0152-3. Epub 2009 Oct 6.
The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits therapeutic promise for prostate cancer. In fact, it interferes with prostate cancer proliferation and metastasis development through the down-regulation of androgen receptor and epidermal growth factor receptor, but also through the induction of cell cycle arrest. It regulates the inflammatory response through the inhibition of pro-inflammatory mediators and the NF-kappaB signaling pathway. These results are consistent with this compound's ability to up-induce pro-apoptotic proteins and to down-regulate the anti-apoptotic counterparts. Alone or in combination with TRAIL-mediated immunotherapy or radiotherapy, curcumin is also reported to be a good inducer of prostate cancer cell death by apoptosis. Curcumin appears thus as a non-toxic alternative for prostate cancer prevention, treatment or co-treatment.
前列腺癌发生潜伏期长、发病率高，这为我们提供了通过化学预防来干预的机会，以预防或根除前列腺恶性肿瘤。本文概述了姜黄素（二芳基甲烷）的化学预防潜力，姜黄素是一种众所周知的天然化合物，对前列腺癌具有治疗潜力。事实上，它通过下调雄激素受体和表皮生长因子受体，以及诱导细胞周期停滞，来干扰前列腺癌的增殖和转移发展。它通过抑制促炎介质和 NF-κB 信号通路来调节炎症反应。这些结果与该化合物诱导促凋亡蛋白和下调抗凋亡蛋白的能力一致。姜黄素还被报道能够单独或与 TRAIL 介导的免疫疗法或放射疗法联合，诱导前列腺癌细胞凋亡。因此，姜黄素似乎是一种无毒的前列腺癌预防、治疗或联合治疗的替代方法。
