Huang Chao-hua, Deng Wei, Chen Zhuang-fei, Li Ming-li, Lu Su, Jiang Li-jun, Cui Li-qian, Wang Qiang, Ma Xiao-hong, Liu Xie-he, Gong Qi-yong, Li Tao
Psychiatric Laboratory, Department of Psychiatry, Mental Health Center and National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Oct;26(5):490-4. doi: 10.3760/cma.j.issn.1003-9406.2009.05.002.
To explore the role of genetic factors in the brain structural variation by using magnetic resonance imaging scan in schizophrenic patients and their unaffected siblings, and to provide experimental evidence for identifying endophenotype of schizophrenia.
The optimized voxel-based morphometry (OVBM) was used to process the brain magnetic resonance images in 15 first episode drug-naive schizophrenic patients, 19 unaffected siblings of the patients and 38 normal control subjects. The data were analyzed by using general linear model.
Compared to the normal control subjects, significant decreases of gray matter was observed in first episode drug-naive schizophrenia in bilateral temporal lobe, bilateral occipital lobe, left insula, left frontal lobe superior frontal gyrus and right lentiform nucleus medial globus pallidus. Significant increases of gray matter in bilateral parietal lobe, bilateral limbic lobe cingulate gyrus in patients group while compared to controls were also found. In unaffected siblings, significant decreases of gray matter was observed in the right temporal lobe, bilateral occipital lobe, left insula, and left frontal lobe precentral gyrus, and significant increases of gray matter were found in left parietal lobe and bilateral cerebellum posterior lobe. Increased gray matter in left parietal lobe precuneus was found in first episode drug-naive schizophrenia when compared with their unaffected siblings.
There were similar brain structure abnormalities between the first episode drug-naive schizophrenia and their unaffected siblings. Genetic factor may play important role in brain structural abnormality in schizophrenia, which suggested that the brain structural change might be a genetic endophenotype of schizophrenia.
通过对精神分裂症患者及其未患病同胞进行磁共振成像扫描，探讨遗传因素在脑结构变异中的作用，为精神分裂症内表型的识别提供实验依据。
采用优化的基于体素的形态学测量法（OVBM）对15例首发未用药的精神分裂症患者、19例患者的未患病同胞及38名正常对照者的脑磁共振图像进行处理。采用一般线性模型对数据进行分析。
与正常对照者相比，首发未用药的精神分裂症患者双侧颞叶、双侧枕叶、左侧岛叶、左侧额叶额上回及右侧豆状核内侧苍白球灰质显著减少。与对照组相比，患者组双侧顶叶、双侧边缘叶扣带回灰质也显著增加。在未患病同胞中，右侧颞叶、双侧枕叶、左侧岛叶及左侧额叶中央前回灰质显著减少，左侧顶叶及双侧小脑后叶灰质显著增加。与未患病同胞相比，首发未用药的精神分裂症患者左侧顶叶楔前叶灰质增加。
首发未用药的精神分裂症患者与其未患病同胞存在相似的脑结构异常。遗传因素可能在精神分裂症脑结构异常中起重要作用，提示脑结构改变可能是精神分裂症的一种遗传内表型。
