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[Application of fluorescence in situ hybridization in prenatal diagnosis of complex chromosomal abnormalities].

作者信息

Shen Yan-yan, Li Jian, Kong Hui, Wu Hui-nan, Wu Qiong, Ge Yun-sheng, Huang Xin-li, Zhou Yu-lin

机构信息

Xiamen Maternity and Child Health Care Hospital, Xiamen, Fujian, 361003, PR China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Oct;26(5):529-32. doi: 10.3760/cma.j.issn.1003-9406.2009.05.011.

DOI:10.3760/cma.j.issn.1003-9406.2009.05.011
PMID:19806574
Abstract

OBJECTIVE

To investigate the application of fluorescence in situ hybridization (FISH) technique in prenatal diagnosis of complex chromosomal abnormalities.

METHODS

Eleven prenatal diagnosis cases (8 from amniocentesis and 3 from cord blood) with complex chromosomal abnormalities detected by routine G-banding, were further analyzed by FISH.

RESULTS

The FISH technique confirmed the results of balanced chromosome rearrangements detected by G-banding, and clarified the structure of the derivative chromosomes in the 3 amniocentesis samples and the origin of the mark chromosomes in the 2 cord blood samples.

CONCLUSION

FISH can be used to diagnose the complex chromosomal abnormalities accurately in prenatal diagnosis, and can provide very useful genetic information for clinical diagnosis and treatment.

摘要

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