大鼠和刺毛鼠（非洲刺毛鼠）大脑皮质切片中环磷酸腺苷形成的β-肾上腺素能调节差异
Differences in beta-adrenergic regulation of cyclic AMP formation in cerebral cortical slices of the rat and spiny mouse--Acomys cahirinus.
作者信息
Chalecka-Franaszek E, Nalepa I, Vetulani J
机构信息
Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Pol J Pharmacol Pharm. 1990 Jan-Feb;42(1):29-38.
In both the rat and Acomys cahirinus the adrenergic cyclic AMP generating system in the brain is dependent not only on beta-, but also on alpha-adrenoceptors. The relative role of alpha-adrenoceptors is much greater in the Acomys cahirinus. This feature makes the Acomys an interesting animal model for investigating the role of alpha-beta-adrenoceptor coupling in generation of cyclic AMP and the mechanism of action of antidepressant treatment.
在大鼠和埃及刺毛鼠中，大脑中的肾上腺素能环磷酸腺苷生成系统不仅依赖于β-肾上腺素受体，还依赖于α-肾上腺素受体。α-肾上腺素受体在埃及刺毛鼠中的相对作用要大得多。这一特性使埃及刺毛鼠成为研究α-β-肾上腺素受体偶联在环磷酸腺苷生成中的作用以及抗抑郁治疗作用机制的有趣动物模型。
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