Division of Infectious Diseases, State University of New York at Stony Brook, Department of Obstetrics/Gynecology, Stony Brook, NY 11794-8091, USA.
Expert Rev Pharmacoecon Outcomes Res. 2005 Dec;5(6):783-90. doi: 10.1586/14737167.5.6.783.
Growing understanding of the mechanisms and epidemiology of neonatal herpes simplex virus acquisition allows for the development of a new management of the pregnant patient, one that will reduce the risk of transmitting herpes to the newborn. Maternal herpes simplex virus infection, especially acquired during pregnancy, can result in transmission to the newborn. Infection of the CNS of the newborn results in death or significant neurodevelopmental impairment in most of these infected babies. Herpes simplex virus infection acquired prior to or during pregnancy has a physical and psychologic impact on the health of the mother. Newer, more sensitive and specific serology testing for herpes simplex virus in combination with antiviral pharmacotherapy is now recognized as an important option for reducing the risk of herpes simplex virus transmission from mother to newborn. This review discusses new information concerning the prevention, diagnosis and treatment options for the management of herpes simplex virus infection during pregnancy with a focus on the evolving role of prevention.
对新生儿单纯疱疹病毒获得机制和流行病学的认识不断加深，使得对孕妇的管理方法得以发展，从而降低将疱疹病毒传染给新生儿的风险。孕妇单纯疱疹病毒感染，特别是在怀孕期间获得的感染，可能会导致病毒传染给新生儿。新生儿中枢神经系统感染会导致大多数受感染婴儿死亡或严重神经发育障碍。孕妇在怀孕前或怀孕期间感染单纯疱疹病毒会对其健康产生生理和心理影响。现在，更敏感、更特异的单纯疱疹病毒血清学检测与抗病毒药物治疗相结合，被认为是降低母婴传播风险的重要选择。本文综述了妊娠期间单纯疱疹病毒感染的预防、诊断和治疗选择的新信息，重点讨论了预防策略的不断演变。
