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鲤鱼对2,4,6-三氯苯基-4'-氨基苯基醚的蓄积与代谢

Accumulation and metabolism of 2,4,6-trichlorophenyl-4'-aminophenyl ether by carp.

作者信息

Tsuda T, Aoki S, Kojima M, Harada H

机构信息

Shiga Prefectural Institute of Public Health and Environmental Science, Japan.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(1):17-21.

PMID:1980874
Abstract
  1. Accumulation of 2,4,6-trichlorophenyl-4'-aminophenyl ether (CNP-amino) in carp was investigated for 14 days. CNP-amino in carp could be divided into free CNP-amino [CNP-amino(I)] and bound CNP-amino [CNP-amino(II)]. 2. The bioconcentration factors (BCF) of CNP-amino(I + II) in carp were 90 +/- 38 (mean +/- SD, n = 3) for muscle, 402 for liver, 501 for kidney and 5368 for gallbladder after 14 days exposure. 3. 2,4,6-Trichlorophenyl-4'-acetamide phenyl ether (CNP-acetamide) was detected as metabolites of CNP-amino in muscle and viscera of carp.
摘要
  1. 对鲤鱼体内2,4,6-三氯苯基-4'-氨基苯基醚(CNP-氨基)的蓄积情况进行了为期14天的研究。鲤鱼体内的CNP-氨基可分为游离CNP-氨基[CNP-氨基(I)]和结合CNP-氨基[CNP-氨基(II)]。2. 暴露14天后,鲤鱼肌肉中CNP-氨基(I + II)的生物富集因子(BCF)为90±38(平均值±标准差,n = 3),肝脏为402,肾脏为501,胆囊为5368。3. 在鲤鱼的肌肉和内脏中检测到2,4,6-三氯苯基-4'-乙酰氨基苯基醚(CNP-乙酰氨基)作为CNP-氨基的代谢产物。

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