Torikata C, Ishiwata K
Cancer. 1977 Sep;40(3):1194-201. doi: 10.1002/1097-0142(197709)40:3<1194::aid-cncr2820400331>3.0.co;2-7.
Intranuclear tubular structures observed in the cells of an alveolar cell carcinoma of the lung are described. The structures were composed of membraneous tubules, measured about 60 nm in diameter, and had an electron-dense central core. These unusual structures were seen in the nuclei of neoplastic cells (Type II pneumocytes). The nature of the tubular structures remains unsolved, but morphologic characteristics and associated grnaulomatous reaction in the stroma imply the possibility of an unknown virus-like infection.
本文描述了在一例肺肺泡细胞癌的细胞中观察到的核内管状结构。这些结构由膜性小管组成，直径约60纳米，并有一个电子致密的中央核心。这些异常结构见于肿瘤细胞（II型肺泡上皮细胞）的细胞核中。管状结构的性质尚不清楚，但形态学特征及间质中相关的肉芽肿反应提示存在未知病毒样感染的可能性。
