糖化血红蛋白与糖耐量正常个体的内中膜厚度有关。
A1C is associated with intima-media thickness in individuals with normal glucose tolerance.
机构信息
Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.
出版信息
Diabetes Care. 2010 Jan;33(1):203-4. doi: 10.2337/dc09-1009. Epub 2009 Oct 6.
Abstract
OBJECTIVE
One-hour glucose during an oral glucose tolerance test (OGTT) was recently proposed as a valuable marker to identify individuals with normal glucose tolerance (NGT) and increased intima-media thickness (IMT). However, central markers of glycemic control were not considered. The aim of this study was to identify which marker of glycemic control is most informative with respect to the variation of IMT in individuals with NGT.
RESEARCH DESIGN AND METHODS
Cardiovascular risk factors, glucose metabolism (OGTT), and IMT were determined in 1,219 nondiabetic individuals (851 women, 368 men; 558 with NGT).
RESULTS
One-hour glucose and A1C levels were significantly correlated to carotid IMT in individuals with NGT, whereas fasting and 2-h glucose levels were not informative. Only A1C was associated with IMT independent of other confounders, whereas 1-h glucose was not informative. Comparable results were found in the total cohort, including individuals with IFG and IGT.
CONCLUSIONS
A1C was the most informative glycemic marker with respect to IMT in individuals with NGT.
摘要
目的
口服葡萄糖耐量试验（OGTT）1 小时血糖最近被提议作为一种有价值的标志物，用于识别具有正常糖耐量（NGT）和增加的内中膜厚度（IMT）的个体。然而，并未考虑血糖控制的中心标志物。本研究的目的是确定在具有 NGT 的个体中，哪种血糖控制标志物与 IMT 的变化最相关。
研究设计和方法
在 1219 名非糖尿病个体（851 名女性，368 名男性；558 名具有 NGT）中确定心血管危险因素、葡萄糖代谢（OGTT）和 IMT。
结果
在具有 NGT 的个体中，1 小时血糖和 A1C 水平与颈动脉 IMT 显著相关，而空腹和 2 小时血糖水平则没有信息。只有 A1C 与其他混杂因素独立相关，而 1 小时血糖则没有信息。在包括 IFG 和 IGT 个体的总队列中也发现了类似的结果。
结论
在具有 NGT 的个体中，A1C 是与 IMT 最相关的血糖标志物。
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